Tag Archives: Vitamin D

THE DOCTORS 101 CHRONIC SYMPTOMS & CONDITIONS #18: ACTINIC KERATOSES

Red hair and freckles are associated with MCR-1 gene variants, and large areas of skin with lowered melanin protection against the adverse effects of the sun. I have red hair and freckles, for which I was teased. My response was that I had a lot of Iron in my blood, and that the freckles were Rust. This is ironic (no pun intended).

Since becoming an Octogenarian, I have had trouble keeping my Iron levels normal. I live in a beach area, where all the young ladies are sunning themselves to promote the socially desirable “bronze goddess” effect, and all of the older ladies hide their leathery skin and wear broad-brimmed hats.

The sun has a good reputation as a health-giver. Being outside does correlate with a lot of beneficial effects, such as enhancing production of Vitamin D. My recommendation, however biased, is to get your Vitamin D in capsule form, and reduce sun exposure.

SUNSHINE, however salutary, is accompanied by invisible, high energy photons capable of breaking DNA strands, and ultimately causing SKIN CANCER. Not accidentally,Visible light has insufficient energy to break bonds, although the rhodopsin in rods and cones do release electrons if stimulated by light.

Actinic Keratoses are the roughened plaques of skin, often on the face, which have a small but definite risk of turning into Cancer. I have a dermatology check every 6 months for precancerous areas to be frozen and destroyed by CO2 spray.

PREVENTION of UV Skin damage is advisable. I wear a broad brimmed hat and UV-blocking sunglasses (UV can promote cataracts and retinal damage as well) when outside in the sun. When swimming I wear a “rashguard” shirt with UV protection in the fabric.

Also, I try to limit my exposure to the Evening and Morning sun, because the light is warmer, and contains less UV. Even with these precautions, I use Sunscreen creams and lotions. I always wondered how a transparent lotion can block UV light.

The explanation lies in the chemicals contained. Such chemicals as Avobenzone and Homosalicylate actually absorb the energy of UV light. Protect yourself now for later health.

–Dr. C.

FALLS AMONG THE ELDERLY: CONDITIONS & PREVENTION

Falling down is common on both ends of the Human lifespan. Little kids are always falling down, but there isn’t much energy to dissipate, since their mass is small and they don’t have far to fall. Moreover, their bones are pliable.

The Elderly also fall, increasingly, as they age. They have a lot further to fall, and their bones are often brittle and osteoporotic. Injury is quite common, they often break a hip, and may slide into a peogressive deterioration leading to their demise..

Ordinary walking, a “normal gait”, is a very complex activity and requires a lot of information and coordination by the nervous system.

VISION is critical, as you are often navigating through a minefield of stairs, rug edges, slippery objects, lamp cords, tubes and pets. Cataracts may be a problem to be corrected. Multifocal glasses can be a factor.

HEARING can warn of certain hazards or warnings and is important. A FINE SENSE OF TOUCH is required to give you cues as you are walking. Peripheral neuropathy can make walking difficult.

PROPRIOCEPTION, the positional sense of where your extremities are located in space, is a sense we take for granted, but which may deteriorate in time. Proprioception is very important for a normal Gait. The inner ear, with it’s semicircular canals and vestibular apparatus is necessary for proper BALANCE.

Balance can be PRACTICED in a number of ways, like standing on one leg, or merely WALKING a lot. These MULTIPLE SENSES must be COORDINATED by the Thalamus, Corpus Striatum, medulla, Cerebellum, and Cerebral Cortex and instructions sent to the muscles of your Legs, Arms, back and abdomen.

It is mandatory to keep these muscles, your Heart and your body, STRONG and FIT. Factors that make you more likely to have a fall are mostly the reverse of the above, and are called RISK FACTORS.

  • –Previous Falls are the best predictor. More than 2 or 3 in a year is worrisome.
  • –Balance Impairment is best treated by practice.
  • –Decreased Muscle strength. –Visual impairment.
  • –Polypharmacy (more than 4 prescription Meds), or a Psychoactive drug (look up)
  • –Gait impairment, Walking difficulty.
  • –Depression, which is often treated by antidepressants or sleeping pills- Psychoactive drugs.
  • –Dizziness or orthostatic hypotension, which causes a drop in blood pressure on standing. and a number of other problems, often a function of age.

PREVENTION of falls is of course better than treatment of the resulting INJURY. Working on your HEALTH will help the INTRINSIC causes of falls, and that is what we have been discussing.

Preventing the EXTRINSIC causes of falls means working on: –Improving the household safety by putting in railings, getting rid of throw rugs, clutter, and maybe pets( a good friend went into a downward spiral after tripping over his Dog.

Adjusting or eliminating psychoactive drugs and antihypertensive drugs (which often include the beta blockers which worsen orthostatic hypotension.

Interestingly, VITAMIN D supplements were mentioned in 2 references I saw. Apparently Vitamin D reduces falls by increasing MUSCLE STRENGTH.

Please refer to the following Canadian article for a more complete discussion.

–Dr. C.

DR. C’S MEDICINE CABINET: “FOLIC ACID” SUPPLEMENTS

Folic acid has a secure place in my medicine cabinet, and is there for one of the best reasons. In screening for possible causes for heart disease, my doctor ordered a HOMOCYSTEINE LEVEL. The Laboratory value came back elevated.

The treatment given was folic acid. Some background is necessary. Homocysteine is a rather toxic amino acid that can cause heart disease and neurological problems, among other things. If you do not get enough folic acid in your diet with green vegetables, legumes, nuts, eggs and the like (it is hard to be deficient with a good diet), your Homocysteine may become elevated.

You need folic acid to convert Homocysteine to the essential amino acid, Methionine. 10-15% of the population, and up to 30% of older people have elevated Homocysteine levels. Stiffness, slow gait, and heart disease can be related to these elevated levels.

Since I have a good diet, I assume that I have a weak form of an enzyme called Tetrahydrofolate Reductase, which is the rate limiting enzyme in converting Homocysteine to Methionine. A weak enzyme needs more folic acid to do its job. The MDR of Folic acid is 0.4 mg./day. I started supplementing with 1 mg. Daily, without effect on the Homocysteine level. I doubled the dose to 2 mg., and my blood level was still above the upper limits of normal, 15 micromoles/L.. I doubled it again to 4 mg., 2 mg. Twice daily.

Finally my level became normal at 10, This was a decade ago. Recently, I have been doing some research on Alzheimer’s Disease, because a Friend is losing her short term memory. I talked to a neurologist to see if a medical evaluation was mandatory, and found that he has recently BEEN GIVING FOLIC ACID supplements to his AD Patients.

Folic acid deficiency is now being suspected as being a factor in AD! This story is similar to the Vitamin D conundrum. Should I take Vitamin D or not? Am I a “believer” or not. The resolution is easy. You get a Vitamin D blood level.

The lab test will report “normal” if your level is above 20 ng,/ml. I prefer 50, which I achieve with 4000 i.u. Daily supplement. The NFL likes their players to be above 50 to be in best shape. The point is, take a measurement, and then decide.

If you chose to take a Folic acid supplement, I would suggest checking both your Folic acid blood level, and Homocysteine blood level as a reference.

Also, if you take folic (B9) supplements, you should also take extra B12, and B6, since they are involved in the same metabolic pathways. Balance is necessary in metabolism.

–Dr. C

BLOOD TESTS: THE BENEFITS THAT “COMPREHENSIVE METABOLIC PANELS” REVEAL

One of my nurses who was usually in good health developed chronic complaints. She felt tired all the time and had a variety of aches and pains. She has been going through menopause for a long time but this set of problems seem different. Then she broke her arm after sustaining a minor fall. An investigation was in order. I should order some tests, but which ones?

Anemia would explain the fatigue so a CBC was a no brainer. With the surprise fracture, I wanted to cast the net wider, so I ordered a comprehensive metabolic panel.

This is an automated test that was a good value for the amount of information provided, I thought.

Nobody was more surprised than I when the test provided results that were the key to her very rare diagnosis. Her serum CALCIUM was very high, and her alkaline phosphatase was also elevated.

Further evaluation showed her diagnosis to be PRIMARY HYPERPARATHYROIDISM.

Removal of her abnormal parathyroid gland was curative. I have been a big fan of the Comprehensive Metabolic  Panel ever since.

The Panel of 14 tests includes:

  • Glucose – an essential test to check in Diabetes, Seizures and Coma.
  • Sodium, Potassium, Chloride, and CO2 and the associated Anion Gap – can be abnormal in a variety of accidents, and other conditions.
  • BUN and Creatinine – cleared by the kidneys, and become elevated in Renal, or Kidney conditions.
  • Calcium and alkaline phosphatase – reflect bone metabolism, and are sensitive to Vitamin D and parathyroid hormone, as in my nurses case.
  • Albumin and Globulin – important blood proteins. Globulins contain the   important immunoglobulins. A variety of conditions will influence their values.
  • AST (SGOT) and ALT – elevated in liver disease

Type in “Comprehensive Metabolic Panel” in google, and choose from the variety of “hits” to get more information about this “ Sherlock Holmes’ Magnifying Glass” for Physicians.

Medicine would be hard pressed to do without it!

Dr. C.

OPINION: THE BENEFITS OF HIGHLY NUTRITIOUS DIETS

Vitamins and minerals, as we all know, are of critical importance to our health. Gone are the days when scurvy(vitamin C) was the scourge of the high seas, and rickets (vitamin D) was common in the children of smoke-filled industrial cities with insufficient sunlight.

We are in a state of such overabundance that many medical authorities feel that vitamin supplementation merely makes our toilets healthier.

Covid 19, with a deficit of prevention and treatment options, has forced a new appreciation of the role of our immune systems in fending off Covid, and future viral plagues that are certain to follow. Optimum Health has never been more important.

A May 4, 2020, British Medical Journal (BMJ) article highlights the role of vitamins C and D, and minerals, especially Zinc, in functioning of our immune systems. Here are several highlights from the article:

  • Foods that are naturally abundant in vitamin C such as broccoli (60 mg/100 g), blackcurrants (130 mg/100 g), fortified breakfast cereals (up to 134 mg/100 g) and oranges (37–52 mg/100 g)45  should be made accessible to older individuals who are most in need of their nutritional benefits.
  • In the UK 5.5% of men and 4% of women 65 years and over (around 1 in 20) presently have zinc intakes lower than the lower reference nutrient intake (the level below which deficiency could occur).46 The consumption of foods naturally abundant in zinc such as canned crab (5.7 mg/100 g), canned shrimps (3.7 mg/100 g), canned adzuki beans (≈2.3 mg/100 g) and boiled eggs (1.3 mg/100 g) should be encouraged as a supplementation strategy to reinforce immunity.
  • Tolerable upper intake levels (ULs) are intake levels which should not be surpassed as toxicity problems could appear.47 For vitamin D a UL of 50 µg/day is advised and for zinc a UL of 25 mg/day is recommended. 47 There is insufficient evidence to establish UL for vitamin C, but available human data suggest that supplemental daily doses of up to about 1 g, in addition to normal dietary intake, are not associated with adverse gastrointestinal effects.47 Not having an adverse effect, however, is not necessarily indicative of a benefit either, and ongoing trials are warranted.
  • Among those with established respiratory conditions or pneumonia, specific nutrients such as vitamin C, D or zinc could be considered as potential adjuvants to conventional treatment pathways.

Susceptible people, particularly the old, should use every safe measure to stay well.

– Dr. C

Read full article

OPINION: THE IMPORTANCE OF VITAMIN D3 SUPPLEMENTS

EVERYBODY should have a SERUM VITAMIN D level!

The medical establishment has been slowly acknowledging that the importance of vitamin D is not limited to just calcium absorption and the bones, or to the athletes and elderly.The lower limits of normal has been slowly creeping up, as has the RDA.

But how much vitamin D you have in your body depends upon your diet, supplements, how much sunshine your skin gets, how much sunshine is screened out ( sunscreen, melanin), and other factors. Measuring the vitamin D serum level tells you directly.

My own Vitamin D level was at first in the low 20’s (ng./ml.), and I raised it to the low 50’s when I started taking 4,000 I.U. daily, the lower limit suggested by the NFL.

Serum Vitamin D levels cost almost $100. Why not just take 4-6,000 I.U.? For me, adding to  already nauseating handfuls of pills (to be enumerated later) was unappetizing. I needed a Serum D level to convince me.

But I didn’t need to be convinced of the importance (with hospitalized Covid Patients the VITAL importance) of this amazingly versatile Vitamin. Vitamin D tends to benefit the innate immune system, helping to ameliorate infections when they first hit. It then helps to turn off “the first responder” when the “big gun” adaptive immune system kicks in at 5-10 days. Failure of this shift ( with continuing interleukin production) may contribute to the “cytokines storm” of the seriously ill Covid-19 patient.

Many Doctors, inured to “health food industry” hype, give little attention to Vitamin D.  You might need to expressly ask for a vitamin D test on your next visit. I hope you do!

—Dr. C.

Further reading:

Vitamin D is crucial for immune health