There are many types of cells in the human body, and any of them can mutate, and become cancerous. Cells of The immune system are no exception, ironically, even though their one of their jobs is to fight cancer.
The plasma cell is an immune system cell that develops from lymphocytes(B-cells) and specializes in producing “Gamma Globulins”, a type of antibody.
When cancer involves plasma cells In the bone marrow it tends to crowd out the other cells. This can produce bone pain and anemia.
All of the cancer cells come from a single progenitor cell and form a “clone”. This clone produces a large amount of defective protein that would normally be combined with other proteins into the making of antibodies. The large amount of the same protein can often be detected in the urine, as a “Bence Jones” protein.
In modern terminology, the condition is called a “monoclonal gammopathy”. This mass of protein gets into the bloodstream, and can deposit in various tissues, where it is called “amyloidosis”. The kidneys are often damaged in the process of excreting the overproduced, repetitious chains of useless protein.
I had a friend who was a pilot in the military during the Vietnam war. He was around “agent orange”, which was on the news a lot in the 80’s. Agent orange was contaminated by a toxic chemical called Dioxin, which is known to cause cancer. My friend developed a cancer, primary amyloidosis, which is a close relative of multiple myeloma, and in his case produces what is called light chains.
His first warning was an elevated creatinine on a metabolic panel blood test, which pointed to the kidneys. Medical investigation uncovered his plasma cell cancer, and he began treatment. His kidneys eventually started to fail.
His daughter donated one of her kidneys, and currently he’s doing well, since medical treatment curtailed the light chain production.
Please refer to the accompanying Cancer association article on multiple myeloma.
A Mayo clinic article was posted on DWWR on May 25, 2021.
Vitamin D has many beneficial effects, but my comments will be restricted to the effect of vitamin D on cancer.
Interest in this association was started by the observation that certain cancers are less common near the equator, where there is more sunlight exposure, and therefore more natural vitamin D generation in your skin.
The most information on cancer in humans Is available on colorectal, breast, prostate, and pancreatic cancer. Colorectal cancer, highlighted DWW our posting, is the only cancer that apparently is affected by vitamin D.
Several studies have suggested that vitamin D can decrease cancer cell growth, stimulate cell death, and reduce cancer blood vessel formation. Increasing cell death, or apoptosis, is what interests me the most, since this is one of the factors which increases inflammation in aging.
The infographics stated that only 300 international units of vitamin D is necessary to produce a 50 Percent reduction in cancer, and that a healthy diet generally supplies this.
I personally take 5000 international units vitamin D. This produces a blood level of about 60 ng/mL, and what the NFL recommends to keep their players healthy, and well within the maximum recommended level of 120 ng/milliliter.
Excessive vitamin D can produce an elevated calcium blood level, and mine is within normal limits. I take the higher dose because of vitamin D’s other effects, such is benefiting the immune system in a time of Conid-19.
I suggest that you get a vitamin D blood level, and also a calcium blood level if you elect to take more of this useful vitamin.
When it comes to fighting cancer or living with a cancer diagnosis, does what you eat make a difference? On Mayo Clinic Q&A, Dr. John Shin, a hematologist/oncologist, discusses nutrition and cancer.
The genius aspergillus is a Fungus extremely common throughout the world. It is in the air almost everywhere, and it’s estimated that most people breathe hundreds of Aspergillus spores into their lungs daily. It affects almost exclusively people with compromised immune systems or with underlying respiratory illness.
COMPROMISED IMMUNITY is often present in people with diabetes, obesity and malnutrition, The very young and very old, Viral infections, particularly AIDS and Covid, cancer, autoimmune diseases, organ transplants, and the list goes on. With the advances in medicine in the past few decades, people are being kept alive longer, often by suppressing their own immunity.
UNDERLYING REPIRATORY ILLNESS is disease such as asthma, cystic fibrosis, sarcoidosis, tuberculosis and COPD.
When I was in an allergy practice, we were always on the alert for allergic bronchopulmonary aspergillosis in asthmatics who were difficult to control. ABPA at that time was reported mainly in England, which is unsurprising due to the wet British climate: fungi grow especially well where is wet.
Another unusual phenomenon is the Aspergillus fungus ball in the lungs, which is sometimes discovered only by chest x-ray. That such a dense mass of fungi could be tolerated in the lungs without invading the body is a tribute to the immune system‘s efficacy.
Galactomannan is in the cell wall of aspergillus, and can be used as a diagnostic test. PCR can also be used, shades of COVID-19. Of course x-ray, or microscopic study of tissues are also often used.
It is estimated that aspergillosis accounts for around 600,000 deaths annually. Africa, with its large number of AIDS patients, contributes heavily to this. It’s difficult to know how common it is in the United States, because aspergillus is not a reportable illness. Please check with the following mayo clinic article for more information.
Focal One® high-intensity focused ultrasound uses high-intensity sound waves to destroy a cancer tumor. It’s delivered through a rectal ultrasound probe. There are no incisions. Most patients need no pain medication after treatment. And there are fewer side effects than with radiation therapy or prostate removal.
Professor Ashani Weeraratna has been studying the cancer microenvironment in her lab for the past 17 years. Taking into account that the tissues in our bodies change as we age is important when researching cancer biology. She hopes that gaining a better understanding of how the growth of cancer cells is affected by their direct cellular ‘neighbourhood’, especially when we age, could be key to developing better treatments for patients with cancer. Read more in
Multiple myeloma is a relatively uncommon form of blood cancer that affects less than 1% of the U.S. population, according the American Cancer Society. People younger than 45 rarely get the disease, and it occurs more in older men than women. And your risk is doubled if you’re African American.