Tag Archives: Infections

Eye Infections: What Is Herpetic Keratitis?

Herpetic Keratitis is a viral infection of the transparent, frontmost part of the eye, the  cornea.

Herpes 1 or 2  when rubbed into the eye from a cold sore, or contacted from somebody else with herpes, will often affect the cornea. The use of corticosteroid eyedrops or ointment will allow the disease to spread faster.

The symptoms are pain and redness of the eye and are a medical emergency, needing prompt treatment by your doctor to prevent scarring and blindness.

Antiviral eyedrops, such as valacyclovir, are used to treat ophthalmic herpes.

A related condition is ophthalmic zoster, caused by the varicella zoster virus. The VZ virus will produce chickenpox in unimmunized people, go into dormancy in the nervous system, and then resurface, if immunity wanes, as shingles. If the shingles occurs in the ophthalmic division of the trigeminal nerve, affecting the skin near the eye, the cornea  will often be involved. Ophthalmic zoster is also treated by antiviral eyedrops.

The varicella zoster virus is closely related to the herpes simplex virus, and is a member of the same nasty family of viruses.

—Dr. C.

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Infections: The 5 Types Of Viral Hepatitis Explained

Viral hepatitis is an infection that causes liver inflammation and damage. Inflammation is swelling that occurs when tissues of the body become injured or infected. Inflammation can damage organs. Researchers have discovered several different viruses link that cause hepatitis, including hepatitis A, B, C, D, and E.

Diagnosis: The Causes Of Fever Of Unknown Origin

Fever is just one of the number of symptoms that accompany most infections such as Covid and  influenza. When doctors can’t find a diagnosis for the fever, and it lasts for a few weeks, however, it is called fever of unknown origin, or FUO.

There are a bewildering number of illnesses that produce fever, and the mixture of these illnesses is different depending on geographic location, the type of hospital, and socioeconomic conditions.

Just like weight loss of unknown origin, or abdominal discomfort of unknown origin, fever without obvious cause is quite possibly be due to cancer in affluent America, and if you go in early you might have better outcomes with your treatment.

Fever has been known since earliest times, and was often considered a diagnosis on its own. In the past, the great majority of the fevers were infectious, and the outcome grave. In the mid 20th century, when I went to medical school, fevers were still mostly infectious. Antibiotics were the magic bullet, and were unfortunately overused. In underdeveloped countries, infections are still the most common cause, but in the developed world difficult to treat viral infections, autoimmune conditions, and cancer have been gaining in prominence.

When fever becomes excessive, and medication is needed, NSAIDS may be used, and works better on fever from infection than on fever from cancer. The take-home message for me is that if you use Naprosyn for a persistent fever, and isn’t effective, you might notify the doctor.

The motivation for me writing this article came from a very good posting in the New England Journal of medicine. They used a little humor, stating that modern FUO might be called “fever of too many origins”, what with all the indwelling catheters, implanted medical devices, shunts and long hospital stays. There is a separate category made for fever acquired in the hospital.

In people with AIDS, the evaluation is different depending on whether or not they are on treatment.

Tuberculosis is still a very common cause of fever.

Drugs are becoming increasingly responsible for troublesome fevers. In the early days of antibacterial therapy, sulfa  was the only drug available, frequently caused fever.  Now, sulfa is less used, and the penicillin derivatives are more common causes of fever.

If you have a fever, and have been traveling recently, be sure to tell the doctor. Your fever might be due to a tropical parasite such as malaria, particularly if you’ve been to West Africa.

Fever is an evolutionarily conserved body defense reaction and helps a person recover from an infection. The normal body temperature cycles according to the time of day; it is lowest first thing in the morning, and is higher later in the afternoon. The average body temperature used to be 37°C, or 98.6 F., but has been declining in recent decades, and is now about 36.5°C or 97.6°F. The use of electronic thermometers has cut down the amount of time needed to assess the body temperature, but added variability. I still prefer the old-fashioned thermometer.

Taking your temperature by whatever means you have available still remains a good idea when you don’t feel well.

—Dr. C.

Prevention: Side Effects Of Excessive Earwax

Infections: Cryptococcus Neoformans (Fungi)

Cryptococcus neoformans and gattii are fungi that most commonly infect people with immunodeficiency, especially AIDS, which is highly prevalent in Africa. Cryptococcus is the final cause of death in perhaps 25% of AIDS patients and preventative treatment is sometimes used if the lymphocyte count is too low.

It is an opportunistic fungus, with similarities to pneumocystis carina, which is discussed in a previous entry.

The areas in the body most commonly affected are the lungs, the skin, and the brain. The lung and skin, being exposed to the environment, are the most common entry points for the fungus, and the brain is a frequently involved area. Chronic meningitis, where the symptoms include headache, blurred vision, and confusion, is frequently caused by cryptococcus.

Sometimes, in healthy people, the skin can be infected with “pigeon breeders disease”. Pigeon droppings are a very common source of cryptococcus organisms.

Infection In the lung is usually restricted to immunocompromised individuals, who develop cough, shortness of breath, and fever. Pulmonary cryptococcosis is a slowly developing disease, can be mistaken for tuberculosis, and frequently gets into the bloodstream and then into the brain.

Treatment is usually with amphotericin B and flucytosine.

—Dr. C.

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Covid-19 & Flu Can Spark Sepsis, Endangering Heart

THE DOCTORS 101 CHRONIC SYMPTOMS & CONDITIONS #54: ORAL THRUSH


Thrush is an infection of the mouth with an organism called candida albicans. It is most common in the newborn and with young children, but can occur in adults if they have an immune deficiency,  use corticosteroid inhalers, are diabetic, or take broad-spectrum antibiotics.

A combined mother–child problem can occur with breast-feeding mothers in the newborn period. The mother’s  nipples may become infected, giving it to the baby, and they can pass back and forth. A baby who has thrush is also susceptible to diaper rash caused by candida.

There is a sense of irritation and some pain associated with thrush in the mouth, the diaper area, and the nipples. Thrush appears as cottage cheese-like areas on the throat and tongue.

The normal immunity usually keeps thrush at bay. In a newborn, however, the immune system is not fully developed. Sometimes the hormones of pregnancy facilitate thrush in the mother. Diabetes and smoking can also allow thrush.

Sometimes the thrush infection will go down into the swallowing tube, the esophagus, and produce inflammation. This can cause pain on swallowing, and is most common in AIDS and other immunodeficiency states.

Treatment of surface candida infections like throat is usually with Mycostatin– containing mouthwashes or creams. If it spreads beyond the surface, however, you will need more potent medications. Candida albicans is everywhere, and your immunity is your main defense against it.

Keep your immunity as solid as possible naturally, with good sleep, diet and exercise.

—Dr. C.

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DR. C’S JOURNAL: WHAT IS PNEUMOCYSTIS PNEUMONIA?

Pneumocystis is found in the respiratory tract of most mammals and Man. Pneumonia from this organism was extremely rare or unknown before the advent of AIDS.

When the lymphocyte count of a person with AIDS drops below 500, or especially 200, pneumocystis pneumonia is a frequent complication. Symptoms include cough, fever, rapid breathing, and shortness of breath.. The chest x-ray typically shows a “ground glass” appearance, caused by fluid inside the air sacs and throughout the lung. Treatment is usually with trimethoprim sulfa.

Immunosuppressive therapy is often given for organ transplants and auto immune diseases these days. Patients and doctors should be on the lookout for pneumocystis symptoms in this situation. Even long-term corticosteroids can produce enough immunosuppression to allow pneumocystis to invade the body.

Pneumocystis Jeroveci is the causative organism, and used to be called pneumocystis Carini. Doctors suspect this disease when an immuno-suppressed patient, especially AIDS , has a dry cough, with pneumonia and  a very low oxygen concentration, more severe than expected.  Fluid taken from the lung shows several  organisms in little sacks or cysts.

Treatment is with sulfonamids, if they are tolerated. Cortisone must be given not the same time to prevent a severe reaction from absorption of the dead organisms. Pneumocystis is a yeast-like fungus and is also discussed under opportunistic fungal infections.

The following article will give you more information.

—Dr. C.

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DR. C’S JOURNAL: EFFECTS & SYMPTOMS OF LONG COVID

COVID-19 is admittedly a pandemic and has caused much economic and social disruption in the world. Now we learn that it may not be over after a few of weeks of illness. LONG COVID is now an accepted syndrome.

You can tell because of the many clinics for handling it being set up by the NHS in England, and millions in research money being directed towards a solution.

The most disturbing thing to me is that infected but asymptomatic or mildly ill people may get this condition, and have one or more symptoms for a long time .Certainly, those more seriously ill develop long Covid symptoms more commonly.

Long Covid is taking its place with chronic fatigue syndrome, posttraumatic stress disorder and post ICU syndrome as poorly understood conditions. They may in fact be taking place simultaneously, even if they are not identical.

The cause  can  be due to continuing viral infection in older or immune compromised individuals. Vascular damage is another reason that could account for the widespread involvement of practically any organ system that doesn’t go away after a few weeks.

Structural damage to the alveoli of the lungs and other organs can also play a role, which would account for shortness of breath as a prominent persistent symptom. Although it has not been highlighted in the articles that I have read, auto immunity can also be playing a role in long Covid.

This would go along with The myocarditis rarely caused by the mRNA vaccines; perhaps some of the protein sequences of the spike proteins have similar shapes to some human tissues. Name a symptom, and you’ll probably find it listed among the 50 odd symptoms mentioned in the Wikipedia article on long Covid, which is appended to the end of this article.

The most prominent symptoms include extreme fatigue, mental fog, and shortness of breath. Treatment is mainly supportive and general. After ruminating on this condition, it’s going to be quite a while before Yours truly wants to breathe in other peoples air spaces; I plan to continue masking in public, distancing and avoiding large groups.

That being said, I am planning to go out to eat dinner tonight, and can hopefully be placed at the edge of the room. I will inquire as to the vaccination status of our waiter. The people at my table will all be doubly vaccinated, which is not complete assurance of safety, but will help make me feel relatively comfortable.

I also plan on getting a booster shot as soon as it is available. Hopefully, the vaccine incorporating the special mutations of the delta virus will be soon available. You don’t want to be infected by this nasty, promethian shape-shifter. Take care.

–Dr. C

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THE DOCTORS 101 CHRONIC SYMPTOMS & CONDITIONS #44: SYPHILIS (STD)

Syphilis is a venereal disease, or STD, that is unusual,  unique in many ways. First of all, it is one of the few major diseases to have originated in the Americas, the New World, and carried back to Europe most likely by Columbus; Popularized by “guns germs and steel”, the infectious disease traffic was almost all the other way, most famously smallpox which decimated the Native Americans.

A second unusual characteristic is that it’s treatment(penicillin) is known, cheap, easy, and yet Syphillis infects millions of people yearly, most commonly to be sure in the developing world, but also large numbers in America where is helped by AIDS, and spread by men having sex with men.

A third unusual characteristic  is that syphilis can mimic practically any disease. There are three stages.  The first stage is a painless ulcer, usually on the genitals.  After a few weeks, the second stage develops, showing a widespread rash and other symptoms.  After a few more months, problems develop in the heart, brain, or growths ( gummas) in many other areas .

When I was in medical school we used to go to an old peoples home to listen for aortic regurgitation, and observe the neurologic symptoms of syphilis patients. Syphilis is still a cause of aortic  insufficiency, if untreated.

Treponema pallidum, The causative agent, is also unusual. It has a very small geome, and has many missing cellular mechanisms, making it dependent upon Homo sapiens, it’s only known Reservoir. The fragile but very active organism will die in a few hours outside of its human host. Like it’s confederate,AIDS, The infection can easily spread from mother to child with devastating consequences. It is one of the major diseases for which pregnant mothers are tested.

Syphilis is one of the best arguments for being monogamous. If this can’t be, remember that syphilis is easily treatable, and that you should report any unusual illnesses to your doctor.

—Dr. C