Category Archives: Videos

COVID-19: HOW BIONTECH USED ITS CANCER RESEARCH TO CREATE A VACCINE (CNBC)

Over a month and a half before the World Health Organization officially declared a pandemic, BioNTech CEO Uğur Şahin met with his wife, BioNTech’s co-founder and chief medical officer Özlem Türeci, and together they agreed to redirect most of the company’s resources to developing a vaccine. Up until that point, BioNTech was little-known internationally and primarily focused on developing novel cancer treatments. The founders were confident in the potential of their mRNA technology, which they knew could trigger a powerful immune response. That confidence wasn’t necessarily shared by the broader medical community. No mRNA vaccine or treatment had ever been approved before. But the couple’s timely breakthrough was actually decades in the making. CNBC spoke with Şahin and Türeci about how they, along with Pfizer, created a Covid-19 vaccine using mRNA.

COMMENTARY:

This commentary concerns a video showing aspects of the development of MRNA vaccines. It is all about Pfizer’s German partner, BioNtech, which manufactures the vaccine. They have produced the bulk of the worlds mRNA vaccines, due to Pfizer‘s great financial strength and  experience in marketing.

Moderna, a wholly American company and by comparison a small fry, has also been doing decades of work with mRNA platform technology, mainly on cancer treatment.

With $800 million from the U.S. government, Moderna was able to scale up their manufacturing process and deliver a vaccine, approved by the FDA, shortly after Pfizer did so.

These vaccines were made possible by two technical advances.
The first advance was in substituting pseudouridine for uridine in the mRNA, so that the target cells natural defenses would not destroy it. The second involves coating the mRNA with a nano size particle to get it into the target cell.

Each of these advances will probably receive a Nobel prize, and is an elegant example of the sophistication of modern  biotechnology.

—Dr. C.

Type 1 Diabetes: How To Treat Hyperglycemia

In this video, you’ll learn the basics of how to treat a high blood glucose result with a Correction Dose of insulin, how to calculate the Correction Dose, and when not to give a Correction Dose.

Type 1 Diabetes: What Causes Hyperglycemia?

In this video, you’ll learn about what causes hyperglycemia, what symptoms to look for, and how it affects the health of people living with type 1 diabetes.

COMMENTARY:

Hyperglycemia refers to an excess of glucose in the blood stream. The fact that we do not all have hyperglycemia is a tribute to the fine-tuned regulation, or homeostasis, of the normal body,

Glucose is our main source of energy especially for the brain. When we eat, our intestinal tract breaks down the complex starches and sugars we eat  into glucose, which is absorbed into the bloodstream. This triggers the pancreatic beta cells to produce insulin, which allows glucose to get through the cell membrane and into our cells.

Hyperglycemia results mainly when pancreas produces insufficient insulin, or our cells exhibit insulin resistance. This can occur in diabetes, other diseases affecting the pancreas or stressful conditions which decreases insulin sensitivity.

Excess of glucose in the blood stream washes out water and salts with excessive urination, causing thirst, and drying out of the cells; the distorted vision of hyperglycemia is one such symptom thot results.

In the most common types of hyperglycemia, the cells are starved of glucose, and need to  breakdown fats for energy. This produces a ketosis, or acidosis of the bloodstream, increasing  the dehydration.

My wife suffered from diabetes, and had her only severe episode in Canada. She started vomiting before we discovered the high blood sugar, and couldn’t drink enough fluids by mouth. She was hospitalized in Canada and received excellent treatment with intravenous fluid and insulin.

Over the years, chronic excess of sugar attached to the protein of her cells, as manifested by excessive hemoglobin A-1 C, or glycohemoglobin, in her bloodstream. She passed away a decade ago.

A healthy lifestyle, with good sleep, diet and exercise is essential
Sugar should be considered a poison.

Regular vegetables fruits and cereal grains help avoid the excess sugar of fast foods. Exercise helps to utilize extra sugar and mitigate stress.

Please refer to the article on hyperglycemia by the Mayo clinic for a more complete discussion.

—Dr. C.

Read morehttps://www.mayoclinic.org/diseases-conditions/hyperglycemia/symptoms-causes/syc-20373631

COVID-19: MOLNUPIRAVIR – MERCK’S ANTIVIRAL DRUG

Molnupiravir (MK-4482, EIDD-2801) is an investigational oral antiviral medicine that significantly reduced the risk of hospitalization or death at a planned interim analysis of the Phase 3 MOVe-OUT trial in at risk, non-hospitalized adult patients with mild-to-moderate COVID-19. At the interim analysis, molnupiravir reduced the risk of hospitalization or death by approximately 50%; 7.3% of patients who received molnupiravir were either hospitalized or died through Day 29 following randomization (28/385), compared with 14.1% of placebo-treated patients (53/377); p=0.0012. Through Day 29, no deaths were reported in patients who received molnupiravir, as compared to 8 deaths in patients who received placebo.

Health: Distinguishing Between Flu & Covid-19

TREATING DEPRESSION: DEEP BRAIN STIMULATION (UCSF)

UCSF Health physicians have successfully treated a patient with severe depression by tapping into the specific brain circuit involved in depressive brain patterns and resetting them using the equivalent of a pacemaker for the brain.

COMMENTARY:

UCSF is my medical alma mater, and I am proud to comment on their info graphic about need-driven deep brain stimulation (DBS). This is not only a good idea, it should spearhead a personalized wave of the future.

Your body’s metabolism is a great balancing act, and needs to be kept on an even keel, to maintain the stability of your internal environment. What is “good” at one time may be deleterious at another.

Good illustrations of this are insulin and thyroid hormone. Both too little and too much is deleterious.

Likewise, the need for DBS varies.. This was recognized by the designers of feedback-driven DBS. The amygdala is overactive when the depressive wave is greatest, triggering the deep brain stimulation. As the depressive wave lightens, the stimulation diminishes or stops.

Engineers are quite attentive to this idea.  A similar feedback mechanism is used by implanted heart stimulators, or “ defibrillators“. if the heart slows down excessively, there is stimulation of the atrium to restore the proper rate. If the ventricle is ineffective, and fibrillates, it is given a shock which acts like rebooting your computer.

Chronotherapy, the administration of medication depending upon the time of day, is a kindred idea, illustrated by asthma. Wheezing attacks peak at night, when adrenaline and cortisol ebb, and so should the blood levels of the anti-asthmatic medication, theophylline.

Another illustration is the medication omeprazole, a proton pump inhibitor that reduces stomach acid. Reflux of this acid into the esophagus increases when you are recumbent and sleeping.. The need for the antacid is therefore greatest at night.

It is estimated that the effects of at least 50% of all medications would  benefit by attending to the diurnal cycles. If your symptoms cycle with the sun, ask your doctor about your medications.

—Dr. C.

SCIENCE & MEDICINE: STORY BEHIND THE MRNA VACCINES

As mRNA-based COVID-19 vaccines are deployed to protect hundreds of millions of people across the world from the deadly global pandemic, the University of Pennsylvania scientists whose research breakthroughs laid the foundation for swift vaccine development have been awarded the 2021 Lasker-DeBakey Clinical Medical Research Award. Here, mRNA vaccine pioneers Drew Weissman, MD, PhD, and Katalin Karikó, PhD, share the story behind their development of this groundbreaking technology, and what it means for the future of medicine.

Brain Health: How To Recognize Strokes (Video)

If you don’t know the signs of a stroke, you’re not alone. Thirty percent of people under the age of 45 don’t either. The key is to B.E. F.A.S.T. Learn how this acronym can help you save a life. The information in this video is accurate as of 9.17.21 and is for information purposes only. Consult your local medical authority or your healthcare practitioner for advice. Resources: Stroke: Causes and Prevention: https://cle.clinic/3hIHtab Stroke Signs & Symptoms: https://cle.clinic/3oLyQhc Stroke Risk Factors: https://cle.clinic/3hJ8r1s

Telemedicine: Many Men Now Prefer Virtual Visits

Cleveland Clinic National Survey Finds Some Men Prefer Seeing Their Doctor Virtually

National MENtion It® campaign examines shift toward the use of virtual healthcare after Cleveland Clinic sees 37,000 virtual visits in 2019 increase to 1.2 million in 2020.

A new national survey by Cleveland Clinic reveals that some men prefer seeing their doctor virtually, especially when it comes to discussing men’s health issues.  

According to the survey, 44% of all men said they prefer discussing sexual health issues with a doctor online or over the phone because they are too embarrassed to do it in person, and 66% of all men have used digital health services in the past 12 months. Cleveland Clinic, which went from 37,000 virtual visits in 2019 to 1.2 million in 2020, is fully open for in-person care but continues to see the trend toward increased use of virtual healthcare in 2021.

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