This Friday, March 17, is World Sleep Day, an annual event that aims to raise awareness of the importance of getting a good night’s sleep. This year’s campaign tagline is “Sleep is essential for health.” According to a study by the American College of Cardiology, up to 8 percent of deaths from any cause could be attributed to “poor sleep patterns”, while those with healthier sleep habits are less likely to die prematurely.
Data from Statista Consumer Insights shows that in the United States, 39 percent of respondents said they had suffered from a sleep disorder (problems falling asleep or staying asleep, insomnia, etc.) in the 12 months prior to the survey. Italians were among the worst sleepers in the survey at 48 percent reporting a sleep disorder, while India registered a higher share of good sleepers, with only 26 percent suffering from poor sleep.
American Thoracic Society (February 24, 2023): A new American Journal of Respiratory and Critical Care Medicine study suggests that COVID-19 lung disease leads to overproduction of mucus in the distal parts of the lungs.
The study investigated airway mucus and mucins in COVID-19 autopsy lungs and showed that both were elevated due to infection, especially during subacute and chronic stages of the disease.
Research on sleep disorders and the importance of regular shut-eye has deepened our understanding of the link between sleep and brain health.
February 2023
Overall, there are more than 80 sleep disorders, ranging from the mildly annoying to the potentially deadly. The best known is probably insomnia; about 10 percent of the general population has chronic insomnia, an inability to fall asleep for multiple nights over a period of months.
Addressing sleep disorders “is paramount to not only protecting the brain down the road but also on a day-to-day basis,” says Daniel Barone, MD, associate medical director of the Weill Cornell Center for Sleep Medicine in New York City and co-author of The Story of Sleep: From A to Zzz (Rowman & Littlefied, 2023). “One of the best ways to take care of our brains is by getting quality sleep.”
Intriguing Clues
Research on sleep disorders has led to improvements in treatment for a variety of sleep and neurologic conditions. Case in point: Studies in the late 1990s on the causes of narcolepsy with cataplexy—the condition Connor was initially diagnosed with—led to the development of dual orexin receptor agonists, drugs now commonly prescribed to treat insomnia. The researchers discovered that people with narcolepsy with cataplexy often had low levels of hypocretins (orexins), brain chemicals that sustain alertness and prevent REM from happening at the wrong time.
“Once they found out, ‘If I take away your hypocretin, it makes you sleepy,’ there was a new idea of how to make a sleeping pill,” says Rafael Pelayo, MD, clinical professor of psychiatry and behavioral sciences at Stanford University School of Medicine in California and a sleep specialist at the university’s Sleep Medicine Center.
“We found that the information we could get from PSMA scanning in patients with newly-diagnosed prostate cancer before surgery was at least as reliable and useful as other information from biopsy, PSA levels, or clinical exam for predicting how patients would do after surgery or other treatment,” says Farshad Moradi, a radiologist at Stanford who co-authored the study.
In December, scientists at Stanford University reported promising findings with a new technology that lights up prostate tumors on specialized imaging scans. The approach relies on a minimally-radioactive tracer that travels the body hunting for cancer cells.
Called 68Ga-PSMA-11, and delivered intravenously, the tracer binds exclusively with a protein called prostate- specific membrane antigen (PSMA). Prostate cancer cells contain far more of this protein on their surfaces than normal prostate cells do. Tumors flagged by 68Ga-PSMA-11 show up on an imaging scan like lit matches in a dark room. Doctors are already using PSMA scans to diagnose early metastatic cancer, and the tracer can also be used to ferry drugs directly into malignant tumors.
In one study published in JAMA Open Network, researchers found that 87% of the preliminary diagnoses made during telemedicine appointments were later confirmed during in-person appointments.
To put it simply: diagnoses over video are usually spot on.
December 2, 2022 – Researchers evaluated more than 97,000 video visits across Mayo Clinic between March and June 2020. Of those visits, 2,400 patients had a visit for a new health concern and followed up with an in-person appointment within 90 days.
The highest rate of matching telemedicine and in-person diagnoses was found in specialties that included psychiatry and psychology, allergy and immunology, orthopedics, and urology. While diagnostic concordance was slightly lower in specialties such as dermatology and ear, nose and throat (ENT), still, close to 80% of those diagnoses were confirmed in person.
“The data we analyzed suggested a nearly threefold reduction in revision surgery in patients who received bone marrow aspirate concentrate, compared to those who did not,” says Bradley Schoch, M.D., an orthopedic surgeon and principal investigator. “This procedure is growing in use throughout the practice of orthopedic surgery and commonly added as a surgical adjunct to rotator cuff tears.”
Mayo Clinic researchers analyzed the largest set of data available to determine if adding bone marrow aspirate concentrate to repaired tissue after standard rotator cuff surgery would improve outcomes for patients. Bone marrow aspirate is fluid taken from a patient’s bone marrow that contains concentrated growth factors, stem cells and other specialized cells that may regenerate tissue and cartilage.
The analysis identified 760 patients who had a regenerative intervention added to augment rotator cuff repair surgery. Those patients were compared to 3,888 patients who did not have any biologic intervention at the time of surgery. The data indicated that 114 patients who opted for bone marrow aspirate concentrate at the time of surgery were less likely to need a second surgery.
Low vitamin D levels were linked with an increased risk of both dementia and stroke over the following 11 years. Based on this observational study, people with low vitamin D levels were found to have a 54% greater chance of developing dementia compared with people whose levels were normal.
A study published online April 22, 2022, by The American Journal of Clinical Nutrition suggests vitamin D deficiency may raise risk for dementia and stroke.
The study analyzed more than 294,000 people (most of them women over 60) living in the United Kingdom. Using blood tests on all participants and neuroimaging tools on about 34,000, researchers looked for associations between vitamin D levels and risks of dementia and stroke. A normal blood vitamin D level was defined as at least 50 nanomoles per liter (nmol/L); a deficiency was defined as less than 25 nmol/L.
“Our study showed that the highest level of patient satisfaction within telemedicine visits was actually among patients within the 65 to 79-year-old age range—which has been an age group often seen as resistant to this mode of care,” says Bart Demaerschalk, M.D., a Mayo Clinic neurologist and senior author. “These findings show how important it is that health care organizations don’t exclusively target telemedicine to their younger, more tech-savvy patients.”
Mayo Clinic, November 3, 2022 – In one of the largest studies to date of its kind, Mayo Clinic researchers found patient satisfaction ratings to be equivalent for video telemedicine visits and in-person clinic visits. These findings highlight the potential for the use of telemedicine across a variety of patient populations.
The study, published in the Patient Experience Journal, evaluated patient satisfaction scores from over 300,000 patients treated either in-person or via video telemedicine during the COVID-19 pandemic.
While researchers found that patient satisfaction ratings were overall equivalent across the two modes of care, they did observe several interesting trends within certain age groups, genders, and races, which countered historical perceptions of telemedicine and represent opportunities for future study.
The body is complicated! While organs in your body each have a specific job to do to keep you healthy, they still rely on each other to function well. When one organ isn’t working the way it should, it can put stress on other organs, causing them to stop working properly as well.
The relationship between chronic kidney disease (CKD), diabetes, and heart disease is one example of the ways our organs are connected.
The body uses a hormone called insulin to get blood sugar into the body’s cells to be used as energy. If someone has diabetes, their pancreas either doesn’t make enough insulin or can’t use the insulin it makes as well as it should.
If someone has CKD, their kidneys are not able to filter out toxins and waste from their blood as well as they should.
Heart disease refers to several types of heart conditions. The most common condition, coronary artery disease, leads to changes in blood flow to the heart, which can cause a heart attack.
Make the Connection
So how are these three conditions connected? Risk factors for each condition are similar and include high blood sugar, high blood pressure, family history, obesity, unhealthy diet, and physical inactivity.
High blood sugar can slowly damage the kidneys, and, over time, they can stop filtering blood as well as they should, leading to CKD. Approximately 1 in 3 adults with diabetes has CKD.
When the kidneys don’t work well, more stress is put on the heart. When someone has CKD, their heart needs to pump harder to get blood to the kidneys. This can lead to heart disease, the leading cause of death in the United States. Change in blood pressure is also a CKD complication that can lead to heart disease.
Luckily, preventing or managing one condition can help you prevent and manage the others and lower the risk for more complications.
Often described as the silent thief of sight, glaucoma is the most common cause of irreversible blindness in the world. High pressure in the eye damages the optic nerve, first stealing peripheral vision (what you see at the corners of your eyes) and later harming central vision (what you see when looking straight ahead). Usually, people notice no symptoms until vision loss occurs.
Lowering high eye pressure is the only known treatment to prevent or interrupt glaucoma. But does everyone with higher-than-normal eye pressure need to be treated? A major long-term study provides some clues, though not yet a complete answer.
Does everyone with high eye pressure develop glaucoma?
In the US, glaucoma affects an estimated three million people, half of whom do not know that they have it. An ophthalmologist can perform a comprehensive eye exam to determine if someone has glaucoma, or is at risk for developing it in the future due to high eye pressure (ocular hypertension). Research from the long-running Ocular Hypertension Treatment Study (OHTS) shows that some people with high eye pressure may never develop glaucoma, while others will.
Doctors Without Waiting Rooms 