Mayo Clinic (March 6, 2023) – About 15% of adults in the U.S. are estimated to have chronic kidney disease — that’s about 37 million people.
What if those people could be treated with medication that could slow the progression of their disease, and help avoid the need for dialysis and kidney transplantation altogether?
Dr. Naim Issa, a Mayo Clinic transplant nephrologist says there is a class of medications to help people with chronic kidney disease that does just that. He says Mayo Clinic has been incorporating these medications to help patients for the last few years.
March 9 is World Kidney Day, a day aimed at raising awareness about the importance of the kidneys.
NSAIDs are a common pain medication. Younger people with no underlying diseases take them all the time for headaches, sprained ankles, and other injuries.
I have an underlying stomach problem that makes me want to minimize the gastrointestinal side effects when I need an NSAID medication, and for that reason I have 100 mg Celebrex, or celecoxib in my medicine cabinet.
I am fortunate not to have much severe pain, although I do have osteoarthritis in my hand, and infrequent abdominal pain from a small bowel surgery.
Celebrex is my magic bullet whenever I have pain from diverse causes such as in my legs; I do have a very active exercise program of an hour a day in the morning and a half an hour in the evening.
The Cox 2 inhibitor‘s were initially touted as being able to avoid the stomach problems caused by the non-selective NSAIDs. Unfortunately, several of them, such as vioxx, were associated with more heart attacks, a 45% increase, and they were removed from the market . Celebrex was a survivor from this group, but it still tends to cause an increase in blood pressure.
Whenever you take any medication, it’s always a trade-off; relief from the problem at hand, traded for the inevitable side effects. There is no powerful medication that has only the desired activity, and most people are better off with a healthy lifestyle than taking medication.
Another advantage with medication avoidance is that when you take the medication, it tends to work a whole lot better. At least I have found that to be true, and celecoxib is my magic pain medication, which has salvaged countless nights of sleep.
Messenger RNA—or mRNA—vaccines have been in development for decades, and are now approved for use against COVID-19. Here’s how they work and what you should know about them. Visit https://www.jhsph.edu/covid-19 for even more resources.
Statins are a type of medication used to lower the level of bad cholesterol in the blood and reduce build-up in arteries that can cause a heart attack or stroke. This short animated video explains the importance of statins, how they work, and why your doctor may prescribe them.
President Trump’s preferred coronavirus treatment is the focus of a new study suggesting it could cause more harm than good, but not everybody agrees. We discuss the fallout as trials around the world are paused and countries diverge over policy advice.
12:12 Are we rushing science?
Coronavirus papers are being published extremely quickly, while normally healthy scientific debate is being blown up in the world’s press. Is there a balancing act between timely research and accurate messaging?
18:49 One good thing
Our hosts pick out things that have made them smile in the last week, including hedgerow brews and a trip into the past using AI.
Eliquis nicely illustrates my contention in the Overview of Metabolism, that the body is a vast collection of pathways, or “supply chains”. Eliquis blocks a critical enzyme in the pathway leading to coagulation, or clotting” as the product.
Why in the world you want to block clotting? The staunching of blood flow, clotting, has saved countless hordes of early, Paleolithic humans, and continued useful through the bloody Roman and Medieval times, right through the violent 20th Century.
Recently, however, wars are becoming somewhat less popular, and eating excessively more popular, leading to a strange situation. Our evolutionarily-preserved CLOTTING mechanism is now leading to MORE problems than it is solving.
Obesity and type 2 Diabetes are leading to the production of so much fat, that it has to be stored in our arterial walls, clogging the blood flow to our Hearts and Brain, among other areas. This, and the somewhat surprising trend towards longer lives has led to an increase in a variety of age-related illnesses.
When I reached 80 years of age I developed Atrial Fibrillation, a condition leading to a tendency to form clots in my quivering atria, the upper chambers of my heart. To decrease the likelihood of clots getting into my blood stream, lodging in my brain and causing STROKE, my cardiologist started me on Eliquis, an anti-coagulant/blood thinner.
Drugs have three names. The proprietary name, Eliquis in this case, is given by the patenting company to be memorable; q,z,and x are popular letters. The second is the FDA drug name, Apixaban. The drug name often gives the doctor a clue as to its type: xaban refers to inhibiting (banning) of factor 10a (Xa). The third name is a chemical name of interest to biochemists and drug researchers.
When I started the Eliquis, at first unknown to me, I started to bleed internally, leading to a drop in my hemoglobin down to 8.6. I will go into this story when I start going through “how to read your laboratory report”.
I found that reducing my Eliquis from 5mg. to 3.75 mg. allowed me stabilize my hemoglobin by taking extra iron, which I will discuss later.
The doseage selected when the drug company markets a drug is fairly arbitrary, and usually involves round numbers. Interestingly, there is a 2.5mg. Eliquis, which is given if you meet 2 out of 3 criteria. I meet only one and am only 5 pounds shy of the second, in case you think (like my cardiologist does) that I’m taking a risk.
I believe that, whenever you are given a medication, you should be educated about the medicine, and the problem it is intended to benefit. Today’s physician often does not have the time to do this. The internet, including this website, offers a corrective.
I am trying my best to be helpful to you as a Patient Advocate. You and I both must have a doctor to rely upon. But to get the most out of our care, WE MUST BE INFORMED.
Empowering Patients Through Education And Telemedicine