Chronic pain can develop from an acute pain state. The mechanisms mediating the transition from acute to chronic pain remain to be elucidated. Here, Parisien et al. focused on the immune system using samples from patients and animal models. Transcriptomic analysis in immune cells from subjects with low back pain showed that neutrophil activation–dependent inflammatory genes were up-regulated in subjects with resolved pain, whereas no changes were observed in patients with persistent pain. In rodents, anti-inflammatory treatments prolonged pain duration and the effect was abolished by neutrophil administration. Last, clinical data showed that the use of anti-inflammatory drugs was associated with increased risk of persistent pain, suggesting that anti-inflammatory treatments might have negative effects on pain duration.
Tag Archives: NSAID's
DR. C’S MEDICINE CABINET: ‘CELEBREX’ (NSAID)
NSAIDs are a common pain medication. Younger people with no underlying diseases take them all the time for headaches, sprained ankles, and other injuries.

I have an underlying stomach problem that makes me want to minimize the gastrointestinal side effects when I need an NSAID medication, and for that reason I have 100 mg Celebrex, or celecoxib in my medicine cabinet.
I am fortunate not to have much severe pain, although I do have osteoarthritis in my hand, and infrequent abdominal pain from a small bowel surgery.
Celebrex is my magic bullet whenever I have pain from diverse causes such as in my legs; I do have a very active exercise program of an hour a day in the morning and a half an hour in the evening.
The Cox 2 inhibitor‘s were initially touted as being able to avoid the stomach problems caused by the non-selective NSAIDs. Unfortunately, several of them, such as vioxx, were associated with more heart attacks, a 45% increase, and they were removed from the market . Celebrex was a survivor from this group, but it still tends to cause an increase in blood pressure.
Whenever you take any medication, it’s always a trade-off; relief from the problem at hand, traded for the inevitable side effects. There is no powerful medication that has only the desired activity, and most people are better off with a healthy lifestyle than taking medication.
Another advantage with medication avoidance is that when you take the medication, it tends to work a whole lot better. At least I have found that to be true, and celecoxib is my magic pain medication, which has salvaged countless nights of sleep.