Tag Archives: Alcohol Consumption

Research, Reviews, Studies

STUDIES: ALCOHOL ABUSE INCREASES CHRONIC PAIN

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Scripps Research (April 21, 2023) – Chronic alcohol consumption may make people more sensitive to pain through two different molecular mechanisms—one driven by alcohol intake and one by alcohol withdrawal. That is one new conclusion by scientists at Scripps Research on the complex links between alcohol and pain.

The research, published in the British Journal of Pharmacology on April 12, 2023, also suggests potential new drug targets for treating alcohol-associated chronic pain and hypersensitivity.

“There is an urgent need to better understand the two-way street between chronic pain and alcohol dependence,” says senior author Marisa Roberto, PhD, the Schimmel Family Chair of Molecular Medicine, and a professor of neuroscience at Scripps Research. “Pain is both a widespread symptom in patients suffering from alcohol dependence, as well as a reason why people are driven to drink again.”

Alcohol use disorder (AUD), which encompasses the conditions commonly called alcohol abuse, alcohol dependence and alcohol addiction, affects 29.5 million people in the U.S. according to the 2021 National Survey on Drug Use and Health.  Over time, AUD can trigger the development of numerous chronic diseases, including heart disease, stroke, liver disease and some cancers.

READ MORE AT SCRIPPS RESEARCH

Dr. C's Journal, Men's Health, Opinion, Women's Health

Doctor’s Journal: ‘Alcohol And Health’

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Alcohol has been used by mankind since before recorded history. It causes a pleasant slowdown of the nervous system, Lessening inhibition  and loosening the tongue, making it the perfect lubricant for social interaction. Unfortunately, it is a metabolic poison.

Excess alcohol use is common enough to have resulted in its prohibition in the United States in the 20s. The side effects of this prohibition proved worse than its benefits, and alcohol currently enjoys the status of one of the few legally permitted Psychoactive drugs.

After diligently searching for beneficial effects of alcohol, society discovered that mild drinking promotes longevity. It is difficult to drink just the right amount of alcohol, and  There is little doubt that excessive drinking is deleterious to the body.

The liver is the organ responsible for getting rid of alcohol. Unfortunately, liver function gradually declines with age, so that the older you get the less alcohol you can tolerate. 14 drinks a week is the suggested upper limits for alcohol’s benefit, and this number shrinks as you get older.

I became interested in alcohol in the elderly because of a friend whose doctor discovered that his red blood cells were enlarged. This can be due to alcohol in at least two different ways. If you drink too much alcohol, you need less calories, and often have a poor diet as a result. B12 (and folic acid) deficiency can result and may cause large red blood cells.

I also learned that alcohol can directly caused large red blood cells because of the toxic effects on the bone marrow, where Red blood cells are made. The very young also have more difficulty with alcohol. Early in my career I discovered 2 young infants who had convulsions after getting into their parents wine closets. These convulsions turned out to be caused by a low blood sugar which developed because glucose, the common blood sugar, is consumed in the process of burning, or metabolizing, alcohol.

My own use of alcohol has been progressively declining with age. I feel good with less alcohol for a shorter time the older I get.

—Dr. C.