Tag Archives: Histamine

THE DOCTORS 101 CHRONIC SYMPTOMS & CONDITIONS #48: URTICARIA (HIVES)

ALLERGY is a type of reaction that can vary from annoying to fatal. The question has always been: what possible utility to the body does the allergic reaction, which has survived evolution, provide? The best theory fingers parasitic infestations; not only can parasites cause allergic reactions, Indicate allergy by showing blood eosinophilia, but the allergic reaction seem to help us fight parasitic infestation, which was much more common in humanity’s  past, and in present day underdeveloped societies.

URTICARIA consists of a number of little welts or bumps that pop up on the skin and are very itchy. This reaction is caused by little darkly-staining cells called MAST CELLS, which release Histamine  and other irritants into the skin, causing hives. These mast cells are provoked into releasing their irritating cargo by IGE antibodies, the basis of true allergy.

Treatment consist of removing the cause, blocking the action of the IgE antibodies, or giving medication to block the action of the histamine( anti-histamines).

There are multiple common causes, several giving its name to a type of Urticaria. Pressure urticaria can be caused by a belt or tight fitting clothing pressing on the skin to cause the hives. Solar urticaria can be caused by sunlight.

Cold urticaria can be caused by exposure to very cold objects. Hives can also be caused stress, exercise, different foods(seafood and strawberries are the most famous), different drugs(penicillin and aspirin are the most famous), and scratching on the skin(dermatographia).

Hives can occur as a feature of ANAPHYLAXIS. If the IgE-mast cell reaction is extensive, the blood pressure can drop, internal organs can be affected, and emergency treatment must take place to prevent death.
My only experience with hives was after a bee sting, when I broke out with itchy bumps. I had desensitization with honeybee venom, although this is not always done these days. Be sure to check with your doctor if you have such a reaction, however.

The biggest recent improvement in treating people who are incapacitated with frequently recurring and long lasting hives is anti-IGE, an expensive but very effective injection.

If you have hives, be sure to keep a record of events that immediately preceded the hives, including foods, activities,, and exposures. Although the recommended Mayo clinic article that follows suggests that you see a dermatologist or an allergist, I would reverse that and suggest the allergist first.

—Dr. C.

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THE DOCTORS 101 CHRONIC SYMPTOMS & CONDITIONS #3: ITCHING WITH DRY SKIN

As I have aged, my skin has been more itchy. My allergy practice was loaded with Patients whose ECZEMA and HIVES itched. My favorite uncle developed intolerable itching (pruritis) in his 90’s, and died within a year of metastatic Prostate Cancer.

This gives you an idea of the Range of this annoying sensation. My emphasis here will be on CHRONIC ITCHING with DRY SKIN in otherwise HEALTHY PEOPLE without much rash or other skin condition. If you want extra discussion, look at Reference #1. If you are a Doctor, or a brute for punishment, see Ref.#2, a CME review.

Your skin is the largest organ in your body, and deserves respect right from birth. The skin of your child is wonderfly healthy in looks and self repair. EXCESSIVE SUN EXPOSURE is about the only thing you need to protect her from, and the only penalty is increased cancer risk in later life.

As your body ages, your skin looses some of its essential oils, and and becomes more dry (at least you don’t get acne any more). You become more sensitive to dry air, like in the winter, when the cold outside air (adiabatically) drops in relative humidity when warmed to inside temperature.

Do you notice the increase in static electricity shocks in the winter? If not, I’m sure that you do notice that your skin itches more. one treatment for the “winter itch” is to humidify the inside air. If you have a draughty old house like I do, it may be more convenient to use MOISTURIZING LOTIONS.

These were once mainstays of itch control in my former practice (before development of the effective modern medications). Eucerin and Cetaphil were very helpful. Maybe it is because of the name, but I now find myself using Curel “Itch Defense” all over my body twice daily,.

The itching is much less now, except for my EARS. My ear canals (they are skin too!) have recently been very dry and itchy, maybe because i listen to podcasts when walking or swimming.

Unwilling to give up my podcasts, I put some UNSCENTED Johnson’s baby oil with my little finger into my ear canals, as suggested by my ENT Doctor (I wanted to be sure i didn’t have a diagnosable condition like a fungal infection). If I have a small spot that itches a lot, I use some 1% Hydrocortisone cream, and I feel better.

Antihistamines don’t do much for me, but are effective if the itching is a real allergy (most of what people call allergy is not the IGE-MEDIATED, “real” variety). HISTAMINE is the quintessential provocateur of ITCH. Cetirizine (or atarax) is the strongest of available antihistamines, and diphenhydramine (benadryl) the old standby.

Chronic itching can be caused by a plethora of illnesses, as you will find if you choose to read the following papers.

– Dr. C

Reference #1

Reference #2