The National Cancer Institute estimates that more than 42,000 new cases of liver cancer will be diagnosed in 2021, representing 2.2% of all new cancer cases in the U.S. The most common type of primary liver cancer is hepatocellular carcinoma.

Other types of liver cancer, such as intrahepatic cholangiocarcinoma and hepatoblastoma, are much less common. “The vast majority of liver cancers — over 90% — occur in patients who have a chronic liver disease,” says Dr. Ilyas. “Cirrhosis, or advanced scarring of the liver, is the strongest risk factor for hepatocellular carcinoma.” Chronic infection with the hepatitis B or hepatitis C viruses also increases your risk of liver cancer.A wide range of treatment options for primary liver cancer are available. Which treatment is used depends on the stage of the disease. On the Mayo Clinic Q&A podcast, Dr. Ilyas discusses liver cancer diagnoses and treatment options, and the importance of prevention.